This paper investigates the role of seaports in the transport system and their importance for economic development. Seaports, as key points in global trade, enable the connection of different parts of the world and facilitate the exchange of goods, thus significantly contributing to the development of national and regional economies. The paper focuses on the analysis of seaports in the European Union, with special reference to their connection with the TEN-T road networks, as well as the role of seaports in the Republic of Croatia. The paper analyzes how seaports act as stakeholders in the economy, with a special focus on their impact on regional economies, the role of port infrastructure in the same, and the impact of globalization on port operations. The final part of the paper deals with the port of Hamburg as an example of a successful port that uses advanced technologies and innovative solutions, which makes it a model for Croatian ports in terms of improving operational procedures and increasing efficiency. In conclusion, the paper highlights the importance of continuous investment in technology and human capital for the sustainable development of seaports. The Port of Hamburg is recognized as a model that Croatian ports can follow in order to improve their operations. The paper also highlights the need to reorient European policies towards fostering innovation and human capital development, which could bring long-term benefits for the competitiveness of seaports and the regions in which they are located.