The porpouse of this research is to examine the effects of fatigue on work performance of the ships crew. Tiredness is one of the factors that negatively affects the work of the crew, and has various negative consequences. The effects of fatigue are very dangerous in the maritime industry. In the maritime traffic, tiredness is associated with a small number of crew members, stress, noise, bad nutrition, boat movements, time zones, sleep deprivation, and usually a large number of hours of continuous work. The postulates of fatigue are great because human errors cause collisions and sinking of ships with people and also having environmental consequences. Tiredness has to be studied very seriously and accessed accurately so that the results of the research are successfully implemented in practice so as to be less accidents. For this purpose, a series of regulations have been introduced to try to minimize the risks and to provide crew members with reduced fatigue and a regular rhythm of rest and sleep. But shipping companies often disgarde maritime regulations due to economic feasibility, burdening crew members and crossing legal boundaries. However, there is an awareness of the need to regulate this topic, because keeping the health and the good mental state of seafarers is in the interest of the entire maritime industries.